scholar 引用：59
頁數：14
發表時間： 18 October 2017
發表刊物：obesity reviews
作者：H. Borgeraas, L. K. Johnson, J. Skattebu, J. K. Hertel, J. Hjelmesæth
作者單位：Morbid Obesity Centre, Vestfold Hospital Trust
摘要：
A systematic review and meta‐analysis of randomized controlled trials was conducted to examine the effects of probiotic supplementation on body weight, body mass index (BMI), fat mass and fat percentage in subjects with overweight (BMI 25–29.9 kg m−2) or obesity (BMI ≥30 kg m−2). MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched for studies published between 1946 and September 2016. A meta‐analysis, using a random effects model, was performed to calculate the weighted mean difference between the intervention and control groups. Of 800 studies identified through the literature search, 15 were finally included. The studies comprised a total of 957 subjects (63% women), with the mean BMI being 27.6 kg m−2 and the duration of the interventions ranging from 3 to 12 weeks. Administration of probiotics resulted in a significantly larger reduction in body weight (weighted mean difference [95% confidence interval]; −0.60 [−1.19, −0.01] kg, I2 = 49%), BMI (−0.27 [−0.45, −0.08] kg m−2, I2 = 57%) and fat percentage (−0.60 [−1.20, −0.01] %, I2 = 19%), compared with placebo; however, the effect sizes were small. The effect of probiotics on fat mass was non‐significant (−0.42 [−1.08, 0.23] kg, I2 = 84%).
Keywords: Meta-analysis, obesity, probiotics, systematic review.
正文組織架構：
1. Introduction
1.1 Objectives
2. Methods
2.1 Protocol and registration
2.2 Eligibility criteria
2.3 Information sources and search strategy
2.4 Data collection
2.5 Data extraction
2.6 Risk of bias within individual studies
2.7 Statistical analysis
3. Results
3.1 Study selection
3.2 Study characteristics
3.3 Risk of bias within studies
3.4 Results of individual studies according to different endpoints
4. Discussion
4.1 Summary of evidence
4.2 Strengths and limitations
4.3 Agreements and disagreements with other studies or reviews
5. Conclusions
正文部分內容摘錄：
1. 健康還是特定疾病？多少個體和組別？就是說這些組別的個體是對健康個體進行干預，還是特定疾病的人在干預？
- Of 800 studies identified through the literature search, 15 were finally included.
- The studies comprised a total of 957 subjects (63% women), with the mean BMI being 27.6 kg m−2 and the duration of the interventions ranging from 3 to 12 weeks.
2. 有哪些組學數據可利用？組學數據的下載ID是什麼？
- Table 1. Characteristics of studies examining the effects of probiotic supplementation on body weight, BMI, fat mass and fat percentage
- The literature search results were uploaded to http://www.covidence.org, which is an internet‐based review program that facilitates review literature screening and collaboration among reviewers.
3. 研究的干預基本結果和結論是什麼？
- Administration of probiotics resulted in a significantly larger reduction in body weight (weighted mean difference [95% confidence interval]; −0.60 [−1.19, −0.01] kg, I2 = 49%), BMI (−0.27 [−0.45, −0.08] kg m−2, I2 = 57%) and fat percentage (−0.60 [−1.20, −0.01] %, I2 = 19%), compared with placebo; however, the effect sizes were small. The effect of probiotics on fat mass was non‐significant (−0.42 [−1.08, 0.23] kg, I2 = 84%).
- Our meta-analysis showed that short-term (≤12 weeks) probiotic supplementation reduced body weight, BMI and fat percentage, but the effect sizes were small.
- Overall, the risk of bias within included studies was low, but, importantly, a number of trials were not registered and/or lacked a priori sample size calculation and were thus regarded as having unclear or high risk of reporting and other biases.
- Accordingly, further long-term studies are required to examine the effects of probiotic supplementation on various measures on body weight.